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It is also possible to use these five commands in the REML analysis (see the section below). GCTA: a tool for Genome-wide Complex Trait Analysis. This option is usually followed by the option --grm (one GRM) or --mgrm (multiple GRMs) to estimate the variance explained by the SNPs that were used to estimate the GRM. The number of starting values specified should NOT be smaller than the number of variance components in the model. By default, GCTA will use equal variances of all the components as the starting values if this option is not specified.